Personas 2 runs in a Silverlight plugin in a web browser. It will run either in NWBC or standalone. It is not affect any of the other GUIs, neither webgui, Windows SAPgui nor JavaGUI.
Personas 3 works in all of the GUIs. The design time part only works in webgui but once built the flavours work in all GUIs. You need Windows or Java SAPgui version 7.40 for this.
Steve.